The Science Behind THRŌS

Understanding how our formula works and why every ingredient matters.

The Science

Methylation. The process behind it.

01

What it is and why it matters.

Methylation is one of your body's most fundamental biochemical processes. It happens billions of times per second, in every cell, and it plays a role in:
- Cardiovascular health
- Cellular energy production
- Fat metabolism
- Neurological function
- DNA production
- Liver detoxification processes
- Eye health
- Histamine balance

Methylation depends heavily on specific nutrients being present in forms the body can readily use — and not all supplement forms are equal.

02

How THRŌS supports it.

THRŌS was formulated with methylation as a core design principle. Five ingredients directly support the cycle:

Vitamin B9

Folate (5-MTHF)

The primary methyl donor in the cycle. An active form of folate that the body can use directly without additional conversion.

Vitamin B12

Methylcobalamin

Works alongside folate to support the methylation cycle. An active, body-ready form of B12.

Vitamin B6

Pyridoxal 5'-Phosphate (P5P)

Supports the transsulfuration pathway, which helps regulate homocysteine metabolism and contributes to cysteine production used in glutathione synthesis.

Trimethylglycine

Betaine Anhydrous

A direct methyl donor that supports an alternative methylation pathway (BHMT pathway), complementing the folate-dependent route.

Vitamin B2

Riboflavin 5’-Phosphate

The active coenzyme form of vitamin B2, involved in cellular energy metabolism and folate-dependent methylation pathways.

03

Why the forms matter.

The body's ability to use B-vitamins in the methylation cycle depends on the form they're delivered in. Standard forms require conversion before they can participate in the cycle.

THRŌS includes forms chosen to be closer to the forms used in the body — including 5-MTHF, methylcobalamin, P5P, and riboflavin 5’-phosphate — helping support direct participation in these pathways.

Most Supplements THRŌS Uses

~~Folic Acid~~

Methylfolate

~~Cyanocobalamin~~

Methylcobalamin

~~Pyridoxine~~

P5P

Active forms provide nutrients in forms closer to those used by the body, reducing the need for extra conversion steps.

The Science

How It Works

This formula is designed to support core biological systems involved in energy production, cognition, recovery, structural health, cellular protection, and hydration.

Where the body produces energy.

Cellular energy powers everything from thinking and movement to recovery and repair. At the center of that process are the mitochondria, where nutrients are converted into ATP — the molecule cells use as fuel. ATP production depends on a steady supply of cofactors, coenzymes, and compounds involved in making, transferring, and recycling energy.

Over time, aspects of mitochondrial function and cellular energy metabolism can change. This formula includes nutrients involved in mitochondrial electron transport, NAD+-dependent energy metabolism, and ATP storage and transfer.

Active CoQ10

Kaneka® Q30 Ubiquinol

The active antioxidant form of CoQ10. Supports mitochondrial electron transport and antioxidant defense within the energy pathway.

Nicotinamide Riboside

A precursor to NAD+, a coenzyme involved in cellular energy metabolism and mitochondrial function.

Creatine Monohydrate

Supports ATP recycling. When cells use ATP, creatine helps regenerate it rapidly in high-demand tissues such as muscle and brain.

Vitamins B1, B2, B5

Essential cofactors that support the enzymatic reactions within the energy metabolism pathway. Each in its active, body-ready form.

THRŌS supports mitochondrial energy through ingredients that work at different stages of the process.

The brain uses more energy than any other organ.Body:

The brain is one of the body’s most energy-demanding organs, and normal cognitive function depends on a steady supply of metabolic, structural, and signaling support. The brain and nervous system rely on steady energy, signaling compounds, and healthy cell membranes to function well.

These systems help drive memory, focus, communication between cells, and normal nerve signaling.

CDP-Choline

Citicoline

Provides choline used to make acetylcholine and supports phospholipid pathways involved in healthy brain cell membranes.

Creatine Monohydrate

Supports cellular energy availability in high-demand tissues such as muscle and brain.

Active Forms

B6 (P5P), B12 (Methylcobalamin), Folate (5-MTHF)

Active forms that support the methylation cycle, neurotransmitter synthesis, and help maintain healthy homocysteine levels already within the normal range.

AstaReal® Astaxanthin

One of the few antioxidants that crosses the blood-brain barrier. Supports antioxidant protection specifically in neural tissue

THRŌS supports brain and nerve function through ingredients that work across multiple pathways:

Hydration happens at the cellular level.

Hydration is not only about how much fluid you drink, but also how well the body maintains electrolyte balance and regulates water movement across cell membranes. Both extracellular fluid balance and intracellular water regulation matter for physical function, cellular stability, and overall performance.

This formula supports hydration from both sides: electrolyte-dependent fluid balance outside the cell and osmotic support within it.

Chelated Form

Magnesium Glycinate

Supports over 300 enzymatic processes including muscle function, nerve signaling, and cellular hydration.

Trimethylglycine

Betaine Anhydrous

An osmolyte that helps regulate fluid pressure inside and outside of cells. Supports cellular hydration at the structural level, not just the surface level.

from Himalayan Pink Salt

Sodium + Chloride

Essential electrolytes for fluid balance and nerve signaling. A clean mineral source without additives

Creatine Monohydrate

Draws water into muscle cells, supporting intracellular hydration and cell volumization. A hydration mechanism most electrolyte products don't address.

Together, these support the body's electrolyte equilibrium — the baseline everything else depends on.

The heart and vascular system depend on energy, mineral balance, and healthy metabolic pathways to function well over time. This includes cardiovascular energy metabolism, normal muscle and nerve signaling, circulation-related pathways, and healthy homocysteine metabolism.

Kaneka® Q30 Ubiquinol

Supports mitochondrial energy production in heart tissue, where energy demand is especially high.

Magnesium Glycinate

Supports normal muscle contraction, nerve signaling, and heart rhythm.

5-MTHF Folate, Methylcobalamin, Betaine, P5P

Support healthy homocysteine metabolism, an important pathway in cardiovascular health.

Vitamin D3

Supports normal muscle function, including tissues involved in cardiovascular performance.

The framework behind everything.

Skin, bone, and muscle all depend on nutrients being absorbed, directed, and used properly. Together, these systems influence structural integrity, movement, muscle function, bone-related physiology, and how tissues respond to oxidative stress over time.

Creatine Monohydrate

Supports cellular energy in muscle tissue and high-demand movement.

Chelated Form

Magnesium Glycinate

Supports muscle contraction, relaxation, and nerve-muscle communication. Plays a role in hundreds of enzymatic reactions involved in structural function.

Trimethylglycine

AstaReal® Astaxanthin

Provides antioxidant support that helps protect cells from oxidative stress, including in tissues like the skin.

Vitamin D3Vitamin K2

D3 + K2 (MK-7)

D3 supports bone mineral density, immune function, and calcium absorption. K2 activates proteins that direct calcium into bones and teeth — and away from arteries and soft tissue. Together they support the entire structural framework: bones, muscle, and the cardiovascular system that connects them.

Protection. From the inside.

Cells are constantly exposed to oxidative stress from metabolism, environment, training, and daily wear. The body relies on antioxidant systems, glutathione-related pathways, repair processes, and immune function to help maintain healthy cellular function over time.

But these defense systems require specific raw materials to function. And as the body ages, the demand increases while the supply decreases. Supporting cellular defense isn't about eliminating oxidative stress — it's about making sure the body has what it needs to manage it effectively.

Kaneka® Q30

Ubiquinol

A lipid-soluble antioxidant that helps protect cell membranes from oxidative damage.

AstaReal®

Astaxanthin

A broad-spectrum carotenoid antioxidant that can span the entire cell membrane, providing protection from both inside and outside the cell. One of the most potent natural antioxidants available.

NAC

N-Acetyl-L-Cysteine

Supports the body's natural production of glutathione, the primary intracellular antioxidant and detoxification agent.

Nicotinamide Riboside

Supports NAD+, which is involved in cellular maintenance and energy-dependent repair processes.

This formula brings together ingredients involved in antioxidant support, glutathione-related pathways, NAD+-dependent repair processes, and normal immune function.

The Folate Pathway

Not all nutrients arrive ready.

Some forms must be converted through multiple enzymatic steps before the body can use them.

Step 1
Folic Acid
Synthetic form — requires conversion
Step 2
~~DHF~~
1st conversion step
Step 3
~~THF~~
Nearly active folate
THRŌS Starts Here
5-MTHF
Active folate — body-ready

Folic acid is the synthetic form used in fortification and many supplements. Before the body can use it in folate metabolism, it must first convert it into active folate forms.

THRŌS provides 5-MTHF — the biologically active circulating form involved in methylation and DNA synthesis — for more direct participation in these pathways.

The form your body uses

DESIGNED WITH INTENTION

Verified For Quality.

Pharmacist-Founded & Formulated

Developed by a licensed pharmacist with a deep understanding of biochemistry and ingredient interactions.

Manufactured in an NSF-Certified GMP Facility

Produced in a U.S. facility that follows strict manufacturing, testing, and quality control standards.

Active Bioavailable Forms

We use metabolically active vitamin forms so nutrients can be absorbed and utilized more efficiently.

Third-Party Tested

Every batch is independently tested to verify purity, potency, and label accuracy.

Cart 0

Sorry, looks like we don't have enough of this product.